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-- -- -- -- hide show operations operations searching home search search genes, proteins or rnas search compounds search reactions search pathways advanced search blast search sequence pattern search google search of this site genome genome browser genome overview regulatory overview browse gene ontology metabolism cellular overview dead-end metabolites chokepoint reactions metabolic route search metabolite translation service browse pathway ontology browse enzyme commission ontology browse compound ontology analysis comparative analysis omics data analysis summary statistics reports history of updates delete history pathway evidence pathway holes pathway curation status reaction curation status help searching website user guide glossary pgdb concepts guide contact us/support features tailoring your own subnetwork exporting leishcyc overview is a community annotated pathway/genome database of trypanosoma brucei , the causative agent of african trypanosomiasis. is maintained at the french national institute of agricultural reasearch (inra) to collect information on the t.brucei metabolism and make it available to the public. was built using a collaborative web platform (trypannot) allowing splitting the annotation efforts between a group of experts each one working on his/her pathways of interest. improves automatic metabolic network reconstruction by adding developmental-stage and compartment information on enzyme activity. these metadata on the network will help generate tailor-made metabolic networks (e.g. metabolic network of procyclic mitochondria) and help understand the parasite metabolism to a greater extend. annotation one of the major objectives of the project is to make it easy for biologists to annotate reactions and provide information regarding the localization of enzyme activity and presence/absence of enzyme activity at various developmental stages of the parasite. mapping, model analysis and sbml export pathway tools provide a set of tools in mapping metabolites, enzymes, genes,reactions and pathways and visualization of experimental data on the model. the metexplore tool can provide additional tools for mapping, visualization, model analysis and sbml export of the whole metabolic network or its subnetworks. coordination of the annotation: flora logan-klumpler fabien jourdan and michael barrett methodological and technical developments: ludovic cottret, florence vinson, and fabien jourdan curator: sanu shameer annotators: flora j logan-klumpler, fiona achcar, michael boshart, matthew berriman, rainer breitling, frédéric bringaud, peter bütikofer, amy m cattanach, bridget bannerman-chukualim, darren j creek, kathryn crouch, harry p de koning, hubert denise, charles ebikeme, alan h fairlamb, michael a j ferguson, michael l ginger, christiane hertz-fowler, eduard j kerkhoven, pascal mäser, paul a m michels, david w nes, archana nayak, derek p nolan, christian olsen, fatima silva-franco, terry k smith, martin c taylor, aloysius g m tielens, michael d urbaniak, jaap j van hellemond, isabel m vincent, shane r wilkinson, susan wyllie, fred r opperdoes and michael p barrett publication: shameer s, logan-klumpler fj, vinson f, cottret l, merlet b, achcar f, boshart m, berriman m, breitling r, bringaud f, bütikofer p, cattanach am, bannerman-chukualim b, creek dj, crouch k, de koning hp, denise h, ebikeme c, fairlamb ah, ferguson ma, ginger ml, hertz-fowler c, kerkhoven ej, mäser p, michels pa, nayak a, nes dw, nolan dp, olsen c, silva-franco f, smith tk, taylor mc, tielens ag, urbaniak md, van hellemond jj, vincent im, wilkinson sr, wyllie s, opperdoes fr, barrett mp, jourdan f. : a community-led biochemical pathways database for trypanosoma brucei. nucleic acids res. 2014 oct 9. pii: gku944. [epub ahead of print] pmid: 25300491 [ abstract , full text , pdf ] reaction curation status please visit the metexplore web site. -- tags) since a non conforming html may affect the entire page. this file must be self contained. -- metexplore + specify list of organism databases select one or more databases: by name by taxonomy my lists a b c d e f g h i j k l m n o p q r s t u v w x y z find in tree: database lists are saved as smarttables that you can edit from your my smarttables page. log in and reload this page to access your saved database lists. current selection 0 databases or taxonomic groups currently selected. note: if you create a user account and log in, you can save your database lists for next time.
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